Accelerated molecular dynamics: a promising and efficient simulation method for biomolecules.

@article{Hamelberg2004AcceleratedMD,
  title={Accelerated molecular dynamics: a promising and efficient simulation method for biomolecules.},
  author={Donald Hamelberg and John T Mongan and J. Andrew Mccammon},
  journal={The Journal of chemical physics},
  year={2004},
  volume={120 24},
  pages={
          11919-29
        }
}
Many interesting dynamic properties of biological molecules cannot be simulated directly using molecular dynamics because of nanosecond time scale limitations. These systems are trapped in potential energy minima with high free energy barriers for large numbers of computational steps. The dynamic evolution of many molecular systems occurs through a series of rare events as the system moves from one potential energy basin to another. Therefore, we have proposed a robust bias potential function… 

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