Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: an early event of DDT carcinogenicity.

@article{Fiorini2008AcceleratedIO,
  title={Accelerated internalization of junctional membrane proteins (connexin 43, N-cadherin and ZO-1) within endocytic vacuoles: an early event of DDT carcinogenicity.},
  author={C{\'e}line Fiorini and J{\'e}r{\^o}me Gilleron and D. Carette and Astrid Valette and Anne Tilloy and St{\'e}phan Chevalier and Dominique Segretain and Georges Pointis},
  journal={Biochimica et biophysica acta},
  year={2008},
  volume={1778 1},
  pages={56-67}
}
Stability of cell-to-cell interactions and integrity of junctional membrane proteins are essential for biological processes including cancer prevention. The present study shows that DDT, a non-genomic carcinogen used at a non-cytotoxic dose (1 microM), rapidly disrupted the cell-cell contacts and concomitantly induced the formation of cytoplasmic vacuoles close to the plasma membrane in the SerW3 Sertoli cell line. High-resolution deconvolution microscopy reveals that this vacuolization process… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Similar Papers

Loading similar papers…