Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment.

@article{Wang2009AcceleratedHA,
  title={Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment.},
  author={Pei-ning Wang and Hsiu-Chih Liu and Jiing-Feng Lirng and K G Lin and Z Wu},
  journal={Psychiatry research},
  year={2009},
  volume={171 3},
  pages={221-31}
}
Studies suggest that smaller hippocampal volume predicts Alzheimer's disease (AD) in mild cognitive impairment (MCI). However, few studies have demonstrated decline rates in cognition and hippocampal volume in MCI subjects with stable clinical presentation. Furthermore, the effects of apolipoprotein E (ApoE) on the change rates of medial temporal structures and cognition in MCI are rarely investigated. Fifty-eight subjects with amnestic MCI and 20 normal aging elderly controls received annual… CONTINUE READING