Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia.

@article{Shimada2012AcceleratedGO,
  title={Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia.},
  author={Hidenori Shimada and Yoshiya Hashimoto and Akira Nakada and Keiji Shigeno and Tatsuo Nakamura},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={417 2},
  pages={659-64}
}
Induced pluripotent stem (iPS) cells are generated from somatic cells by the forced expression of a defined set of pluripotency-associated transcription factors. Human iPS cells can be propagated indefinitely, while maintaining the capacity to differentiate into all cell types in the body except for extra-embryonic tissues. This technology not only represents a new way to use individual-specific stem cells for regenerative medicine but also constitutes a novel method to obtain large amounts of… CONTINUE READING
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