Accelerated flap prefabrication with vascular endothelial growth factor.

  title={Accelerated flap prefabrication with vascular endothelial growth factor.},
  author={Qingsheng Li and Ernane D Reis and Wen Xiao Zhang and Lester Silver and John T. Fallon and Hubert Weinberg},
  journal={Journal of reconstructive microsurgery},
  volume={16 1},
Vascular endothelial growth factor (VEGF) is a potent promoter of angiogenesis that has been shown to enhance revascularization of ischemic tissues, including skin flaps. This study was designed to investigate the value of a single topical application of recombinant human VEGF to accelerate flap viability in a rat model of a non-ischemic prefabricated flap. Prefabricated flaps were created in 48 Sprague-Dawley rats. An autologous tail artery loop was anastomosed to the femoral artery and vein… CONTINUE READING


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