Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model.

@article{Verrier2018AcceleratedCO,
  title={Accelerated conversion of atrial fibrillation to normal sinus rhythm by pulmonary delivery of flecainide acetate in a porcine model.},
  author={Richard L Verrier and Alexandre L Bortolotto and Bruna Adriene Gomes de Lima e Silva and Alexandre A Marum and Fernando G Stocco and Ederson Evaristo and Victor Z de Antonio and Anderson Lucas Carneiro de Lima da Silva and Luiz Belardinelli},
  journal={Heart rhythm},
  year={2018}
}
BACKGROUND Pulmonary delivery of antiarrhythmic agents has the potential to increase rapidly targeted drug concentrations in pulmonary veins and left atrium to terminate atrial fibrillation (AF). OBJECTIVE We evaluated the efficacy of flecainide administered via intratracheal instillation in terminating AF in a reliable preclinical model. METHODS In 11 closed-chest anesthetized Yorkshire pigs, AF was induced by intrapericardial administration of acetylcholine (1 mL of 102.5 mM solution… CONTINUE READING