Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice.

@article{RuizEderra2006AcceleratedCF,
  title={Accelerated cataract formation and reduced lens epithelial water permeability in aquaporin-1-deficient mice.},
  author={Javier Ruiz-Ederra and Alan S Verkman},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 9},
  pages={3960-7}
}
PURPOSE To investigate the involvement of aquaporin (AQP)-1 in lens epithelial cell water permeability and maintenance of lens transparency in experimental models of cataract formation. METHODS Comparative studies were performed on wild-type versus AQP1-null mice. Osmotic water permeability was measured in calcein-stained epithelial cells in intact lenses from fluorescence changes in response to osmotic gradients. Lens water content was measured by gravimetry using kerosene-bromobenzene… CONTINUE READING
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