Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice.

@article{Ota2009AcceleratedCR,
  title={Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice.},
  author={Norikazu Ota and Hironari Takaishi and Naoto Kosaki and Jiro Takito and Masaki Yoda and Takahide Tohmonda and Tokuhiro Kimura and Yasunori Okada and Hisataka Yasuda and Hiroshi Kawaguchi and Morio Matsumoto and Kazuhiro Chiba and Hiroyasu Ikegami and Yoshiaki Toyama},
  journal={Endocrinology},
  year={2009},
  volume={150 11},
  pages={4823-34}
}
Receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG), a decoy receptor of RANKL, maintain bone mass by regulating the differentiation of osteoclasts, which are bone-resorbing cells. Endochondral bone ossification and bone fracture healing involve cartilage resorption, a less well-understood process that is needed for replacement of cartilage by bone. Here we describe the role of OPG produced by chondrocytes in chondroclastogenesis. Fracture healing in OPG… CONTINUE READING

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defect after drill - hole injury by reducing terminal differentiation of osteoblasts in the mouse femur

  • LC Gerstenfeld, DJ Sacks, +7 authors TA Einhorn
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