Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks

@article{Barash2010AcceleratedCF,
  title={Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks},
  author={H. Barash and Eitan R Gross and Y. Edrei and E. Ella and Ariel Israel and Irit Cohen and N. Corchia and T. Ben-Moshe and O. Pappo and E. Pikarsky and D. Goldenberg and Y. Shiloh and E. Galun and R. Abramovitch},
  journal={Proceedings of the National Academy of Sciences},
  year={2010},
  volume={107},
  pages={2207 - 2212}
}
Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and is considered to be the outcome of chronic liver inflammation. Currently, the main treatment for HCC is surgical resection. However, survival rates are suboptimal partially because of tumor recurrence in the remaining liver. Our aim was to understand the molecular mechanisms linking liver regeneration under chronic inflammation to hepatic tumorigenesis. Mdr2-KO mice, a model of inflammation-associated… Expand
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