Accelerated blood clearance of pegylated liposomal topotecan: influence of polyethylene glycol grafting density and animal species.

@article{Li2012AcceleratedBC,
  title={Accelerated blood clearance of pegylated liposomal topotecan: influence of polyethylene glycol grafting density and animal species.},
  author={Chun Li and Jinna Cao and Yajuan Wang and Xi Zhao and Chenxin Deng and Na Wei and Jing Yang and Jingxia Cui},
  journal={Journal of pharmaceutical sciences},
  year={2012},
  volume={101 10},
  pages={
          3864-76
        }
}
Upon repeated administration, empty pegylated liposomes lose long-circulating characteristics, referred to as accelerated blood clearance (ABC) phenomenon. However, pegylated liposomal cytotoxic drug formulations could not elicit the phenomenon. In the study, it was found that repeated injection of pegylated liposomal topotecan could induce ABC phenomenon in Wistar rats, beagle dogs, and mice, which might be associated with the formation of empty liposomes in circulation because of the rapid… CONTINUE READING
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