Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes

@article{Monickaraj2012AcceleratedAA,
  title={Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes},
  author={F. Monickaraj and S. Aravind and K. Gokulakrishnan and C. Sathishkumar and P. Prabu and D. Prabu and V. Mohan and M. Balasubramanyam},
  journal={Molecular and Cellular Biochemistry},
  year={2012},
  volume={365},
  pages={343-350}
}
  • F. Monickaraj, S. Aravind, +5 authors M. Balasubramanyam
  • Published 2012
  • Biology, Medicine
  • Molecular and Cellular Biochemistry
  • Although shortened telomeres were shown associated with several risk factors of diabetes, there is lack of data on their relationship with mitochondrial dysfunction. Therefore, we compared the relationship between telomere length and mitochondrial DNA (mtDNA) content in patients with type 2 diabetes mellitus (T2DM; n = 145) and in subjects with normal glucose tolerance (NGT; n = 145). Subjects were randomly recruited from the Chennai Urban Rural Epidemiology Study. mtDNA content and telomere… CONTINUE READING
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