Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4.

@article{Espeseth2008AcceleratedAC,
  title={Accelerated age-related cortical thinning in healthy carriers of apolipoprotein E epsilon 4.},
  author={Thomas Espeseth and Lars T. Westlye and Anders M. Fjell and Kristine B. Walhovd and Helge Rootwelt and Ivar Reinvang},
  journal={Neurobiology of aging},
  year={2008},
  volume={29 3},
  pages={329-40}
}
Effects of APOE genotype on age-related slopes of cortical thinning was estimated by measuring the thickness of the cerebral cortex on a point-by-point basis across the cortical mantle in 96 healthy non-demented volunteers aged 48-75 years. Fifty nine were APOE epsilon 4- (no epsilon 4 allele) and 37 were epsilon 4+ (1 or 2 epsilon 4 alleles). The genotype groups had similar age, sex and IQ. Two T(1)-weighted MP-RAGE sequences were averaged for each participant to yield images with high signal… CONTINUE READING