Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

@article{Borgesius2011AcceleratedAC,
  title={Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.},
  author={Nils Zuiderveen Borgesius and Monique C. de Waard and Ingrid van der Pluijm and Azar Omrani and Gerben C. M. Zondag and Gijsbertus T. J. van der Horst and David W. Melton and Jan H. J. Hoeijmakers and Dick Jaarsma and Ype Elgersma},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 35},
  pages={12543-53}
}
Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societies with their aging populations. Accumulation of DNA damage has been proposed to contribute to these impairments, but direct proof that DNA damage results in impaired neuronal plasticity and memory is lacking. Here we take advantage of Ercc1(Δ/-) mutant mice, which are impaired in DNA nucleotide excision repair, interstrand crosslink repair, and double-strand break repair. We show that these mice… CONTINUE READING
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Mutational analysis of the human nucleotide excision repair gene ERCC1

  • AM Sijbers, PJ van der Spek, +6 authors JH Hoeijmakers
  • Nucleic Acids Res
  • 1996
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