Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype.

Abstract

We and others recently described a method for isolating viable forkhead boxp3 (FoxP3(+)) T regulatory cells (Tregs) by means of the surface phenotype CD4(+)CD127(lo)CD25(+). In this study, we used the new strategy to measure Treg numbers, phenotype and function at different ages. Mean percentages of CD4(+)CD127(lo)CD25(+) Tregs increased only slightly… (More)
DOI: 10.1093/intimm/dxm151

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