Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models

@inproceedings{Squarize2010AcceleratedWH,
  title={Accelerated Wound Healing by mTOR Activation in Genetically Defined Mouse Models},
  author={Cristiane Helena Squarize and Rogerio Moraes Castilho and Thomas H Bugge and J. Silvio Gutkind},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The management of slow or non-healing ulcerations constitutes an increasing clinical challenge in the developed world because of the ageing of the population and the pandemic rise in type II diabetes. Recent studies suggest that molecular circuitries deployed by tumor cells to promote cancerous growth may also contribute to tissue regeneration. Here, we exploited this emerging information to search for novel molecular targets to accelerate wound healing. METHODOLOGY/PRINCIPAL… CONTINUE READING