Accelerated Emigration of B Lymphocytes in the Xid Mouse 1

The B cell receptor is required for the emigration of newly generated B lymphocytes and for their maintenance in the periphery. A specific maintenance defect was noted in fraction I (IgDIgM ) B cells in Xid mice (which harbor a mutation in Btk). Although Bcl-2 levels in fractions I and II (IgD IgM ) are equivalent in normal and Xid B cells, a novel peak of… (More)