Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages*

@article{He2013AcceleratedDO,
  title={Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages*},
  author={Chao He and A. Ryan and S. Murthy and A. Carter},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={288},
  pages={20745 - 20757}
}
Background: Macrophages play an important role in inflammation and injury as well as resolution of the response. Results: Mitochondrial Cu,Zn-SOD-mediated H2O2 polarizes macrophages to an M2 phenotype. Conclusion: A prolonged predominance of M2 macrophages can induce a fibrotic phenotype. Significance: The antioxidant enzyme, Cu,Zn-SOD, increases mitochondrial H2O2 levels, which is linked to pulmonary fibrosis. Macrophages not only initiate and accentuate inflammation after tissue injury, but… Expand
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