Accelerated Communication GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM- DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS

Abstract

Gemfibrozil more potently inhibits CYP2C9 than CYP2C8 in vitro, and yet the opposite inhibitory potency is observed in the clinic. To investigate this apparent paradox, we evaluated both gemfibrozil and its major metabolite, an acyl-glucuronide (gemfibrozil 1-Oglucuronide) as direct-acting and metabolism-dependent inhibitors of the major drug-metabolizing… (More)

Topics

7 Figures and Tables

Slides referencing similar topics