Accelerated Chromatin Biochemistry Using DNA-Barcoded Nucleosome Libraries

@inproceedings{Nguyen2014AcceleratedCB,
  title={Accelerated Chromatin Biochemistry Using DNA-Barcoded Nucleosome Libraries},
  author={Uyen T. T. Nguyen and Lenka Bittova and Manuel M M{\"u}ller and Beat Fierz and Yael David and Brian Houck-Loomis and Vanessa Wei Feng and Geoffrey P. Dann and Tom W Muir},
  booktitle={Nature Methods},
  year={2014}
}
Elucidating the molecular details of how chromatin-associated factors deposit, remove and recognize histone post-translational modification (PTM) signatures remains a daunting task in the epigenetics field. We introduce a versatile platform that greatly accelerates biochemical investigations into chromatin recognition and signaling. This technology is based on the streamlined semisynthesis of DNA-barcoded nucleosome libraries with distinct combinations of PTMs. Chromatin immunoprecipitation of… CONTINUE READING
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