Accelerated Bone Mass Senescence After Hematopoietic Stem Cell Transplantation

  title={Accelerated Bone Mass Senescence After Hematopoietic Stem Cell Transplantation},
  author={Bianca Serio and Luca Pezzullo and Robert E. Fontana and Silvana Annunziata and Rosa Rosamilio and Mariarosaria Sessa and Valentina Giudice and Idalucia Ferrara and Mark Rocco and Gaetano De Rosa and P. M. Carnevale Ricci and Libuse Tauchmanov{\`a} and Nunzia Montuori and Carmine Selleri},
  booktitle={Translational medicine @ UniSa},
Osteoporosis and avascular necrosis (AVN) are long-lasting and debilitating complications of hematopoietic stem cell transplantation (HSCT). We describe the magnitude of bone loss, AVN and impairment in osteogenic cell compartment following autologous (auto) and allogeneic (allo) HSCT, through the retrospective bone damage revaluation of 100 (50 auto- and 50 allo-HSCT) long-term survivors up to 15 years after transplant. Current treatment options for the management of these complications are… CONTINUE READING


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