Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction.

@article{Sunami2004AcatalasemiaSR,
  title={Acatalasemia sensitizes renal tubular epithelial cells to apoptosis and exacerbates renal fibrosis after unilateral ureteral obstruction.},
  author={Reiko Sunami and Hitoshi Sugiyama and D Wang and Mizuho Kobayashi and Yohei Maeshima and Yasushi Yamasaki and Noriyoshi Masuoka and Norio Ogawa and Shohei Kira and Hirofumi Makino},
  journal={American journal of physiology. Renal physiology},
  year={2004},
  volume={286 6},
  pages={F1030-8}
}
Tissue homeostasis is determined by the balance between oxidants and antioxidants. Catalase is an important antioxidant enzyme regulating the level of intracellular hydrogen peroxide and hydroxyl radicals. The effect of catalase deficiency on renal tubulointerstitial injury induced by unilateral ureteral obstruction (UUO) has been studied in homozygous acatalasemic mutant mice (C3H/AnLCs(b)Cs(b)) compared with wild-type mice (C3H/AnLCs(a)Cs(a)). Complete UUO caused interstitial cell… CONTINUE READING

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