Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia.

@article{Kim2012AcanthoicAI,
  title={Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia.},
  author={Kangil Kim and Young Min Ham and Ji-Young Moon and Minhee Kim and Yong-Hwan Jung and You-Jin Jeon and N. H. Lee and Nalae Kang and Hye-Mi Yang and Daekyung Kim and Chang Woo Hyun},
  journal={Food chemistry},
  year={2012},
  volume={135 3},
  pages={
          2112-7
        }
}
The present study was designed to evaluate the molecular mechanisms of the action of acanthoic acid (ACAN) from Acanthopanax koreanum (Araliaceae) against HL-60 human promyelocytic leukaemia cells. ACAN reduced the proliferation of HL-60 cells in a dose- and time-dependent manner accompanied by the induction of apoptosis. Possible mechanisms of ACAN-induced apoptosis were also examined. The results showed that ACAN-induced the phosphorylation of members of the mitogen-activated protein kinase… CONTINUE READING
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