Acan125 binding to the SH3 domain of acanthamoeba myosin-IC.

  title={Acan125 binding to the SH3 domain of acanthamoeba myosin-IC.},
  author={Henry G. Zot and Venugopal Bhaskara and Li Liu},
  journal={Archives of biochemistry and biophysics},
  volume={375 1},
The domain organization of Acanthamoeba myosin-I, an oligomodular motor protein, includes a potentially important protein interaction module that is mostly uncharacterized. The Src homology 3, SH3, domain of myosin-I binds Acan125, a protein containing at least two consensus ligand binding domains: C-terminal SH3 binding motifs (PXXP) and N-terminal leucine-rich repeats. We report the first affinities determined for an SH3 domain of any myosin, namely, K(d) = 7 microM for a 21-residue synthetic… CONTINUE READING