Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress

@article{Spanagel1998AcamprosateST,
  title={Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress},
  author={Rainer Spanagel and Inge Sillaber and Walter Zieglg{\"a}nsberger and William A. Corrigall and Jane Stewart and Yavin Shaham},
  journal={Psychopharmacology},
  year={1998},
  volume={139},
  pages={391-401}
}
Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid drugs related to their abuse potential. These included sensitization to the behavioral effects of morphine, morphine-induced dopamine (DA) release in the nucleus accumbens (NAS… CONTINUE READING

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Time-dependent changes in cocaineseeking behavior and dopamine overßow in the amygdala during cocaine withdrawal

  • LT Tran-Nguyen, RA Fuchs, GP Co¤ey, LE O’Dell, DA Baker, JL Neisewander
  • Neuropsychopharmacology
  • 1998
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