Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons.

@article{Berton1998AcamprosateEN,
  title={Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons.},
  author={Fr{\'e}d{\'e}rique Berton and Walter Francesconi and Samuel G. Madamba and Walter Zieglg{\"a}nsberger and George Robert Siggins},
  journal={Alcoholism, clinical and experimental research},
  year={1998},
  volume={22 1},
  pages={183-91}
}
Acamprosate (calcium acetylhomotaurine) is used therapeutically in Europe to reduce relapse in weaned alcoholics. However, the mechanisms of acamprosate action in the central nervous system are still obscure, although early studies suggested an action on GABA receptors. The nucleus accumbens (NAcc) is a brain region thought to underlie ethanol reinforcement. Recent studies from our laboratory have demonstrated that ethanol inhibits both N-methyl-D-aspartate (NMDA) and non-NMDA types of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

The indirect NMDAR antagonist acamprosate induces postischemic neurologic recovery associated with sustained neuroprotection and neuroregeneration.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2015

Similar Papers

Loading similar papers…