Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass.

@article{Mathew1995AcadesineIN,
  title={Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass.},
  author={Joseph Palackal Mathew and Christine S. Rinder and Jayne B. Tracey and L A Auszura and Terry O'Connor and Edwin R. Davis and Brian Richard Smith},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1995},
  volume={109 3},
  pages={
          448-56
        }
}
Granulocyte adhesion to ischemic tissue, mediated in large part by beta 2 integrin receptors, is important in the pathophysiology of reperfusion injury. Acadesine, a drug that modulates adenosine levels in ischemic tissue, has been shown to reduce reperfusion injury in animal models of ischemia. The purpose of this study was to measure changes in granulocyte CD11b/CD18 in an in vitro assay and in an in vivo trial of acadesine administered during cardiopulmonary bypass to determine whether this… CONTINUE READING

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