Acadesine extends the window of protection afforded by ischaemic preconditioning.

@article{Tsuchida1994AcadesineET,
  title={Acadesine extends the window of protection afforded by ischaemic preconditioning.},
  author={Akihito Tsuchida and X M Yang and B A Burckhartt and Kevin M. Mullane and Michael V. Cohen and James M. Downey},
  journal={Cardiovascular research},
  year={1994},
  volume={28 3},
  pages={379-83}
}
OBJECTIVE The aim was to test whether acadesine (5-amino-4-imidazolecarboxamide riboside, AICAR), an adenosine regulating agent which increases tissue adenosine during ischaemia, could prolong the window of protection from ischaemic preconditioning. METHODS A branch of the left coronary artery of a rabbit heart was occluded for 30 min and reperfused for 180 min to induce infarction. Infarct size was determined with triphenyl tetrazolium staining. Prior to the 30 min ischaemia, rabbits were… CONTINUE READING