Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.


BACKGROUND Although there are many factors that might contribute to tissue injury during ischemia and reperfusion, the loss of adenine nucleotides has long been considered to be of importance. This has led to the study of interventions designed to limit the loss of nucleotides or to enhance the rate of nucleotide resynthesis during reperfusion… (More)


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