Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain.

@article{Wu2011AcacetinCA,
  title={Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain.},
  author={Hui-Jun Wu and Wei Wu and Hai-Ying Sun and G P Qin and Hong-Bing Wang and Panwen Wang and Hari Krishna Yalamanchili and Junwen Wang and Hung-fat Tse and Chu-pak Lau and Paul Michel Vanhoutte and Gui-Rong Li},
  journal={Journal of molecular and cellular cardiology},
  year={2011},
  volume={51 6},
  pages={966-73}
}
We have demonstrated that the natural flavone acacetin selectively inhibits ultra-rapid delayed rectifier potassium current (I(Kur)) in human atria. However, molecular determinants of this ion channel blocker are unknown. The present study was designed to investigate the molecular determinants underlying the ability of acacetin to block hKv1.5 channels (coding I(Kur)) in human atrial myocytes using the whole-cell patch voltage-clamp technique to record membrane current in HEK 293 cells stably… CONTINUE READING
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