Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.

@article{Hoffman2013AbusePO,
  title={Abuse potential of non-nicotine tobacco smoke components: acetaldehyde, nornicotine, cotinine, and anabasine.},
  author={Allison C Hoffman and Sarah E. Evans},
  journal={Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco},
  year={2013},
  volume={15 3},
  pages={622-32}
}
INTRODUCTION This review identified published animal studies evaluating the possible abuse potential of acetaldehyde, nornicotine, cotinine, and anabasine based on five commonly used paradigms. These include their effects on midbrain dopamine (DA) levels, drug discrimination and substitution for known drugs of abuse, place conditioning, self-administration behavior, and somatic withdrawal symptoms. RESULTS Acetaldehyde had mixed effects on midbrain DA levels and drug discrimination; however… CONTINUE READING
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