Abuse potential of intranasal buprenorphine versus buprenorphine/naloxone in buprenorphine‐maintained heroin users

  title={Abuse potential of intranasal buprenorphine versus buprenorphine/naloxone in buprenorphine‐maintained heroin users},
  author={J. Jones and M. Sullivan and S. Vosburg and J. Manubay and S. Mogali and Verena E Metz and S. Comer},
  journal={Addiction Biology},
  • J. Jones, M. Sullivan, +4 authors S. Comer
  • Published 2015
  • Medicine
  • Addiction Biology
  • In spite of the clinical utility of buprenorphine, parenteral abuse of this medication has been reported in several laboratory investigations and in the real world. Studies have demonstrated lower abuse liability of the buprenorphine/naloxone combination relative to buprenorphine alone. However, clinical research has not yet examined the utility of the combined formulation to deter intranasal use in a buprenorphine‐maintained population. Heroin‐using volunteers (n = 12) lived in the hospital… CONTINUE READING
    26 Citations

    Topics from this paper

    Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment
    • 2
    • Highly Influenced
    • PDF
    New developments in the management of opioid dependence: focus on sublingual buprenorphine–naloxone
    • M. Soyka
    • Medicine
    • Substance abuse and rehabilitation
    • 2015
    • 43
    • PDF
    Opioid system modulation with buprenorphine/samidorphan combination for major depressive disorder: two randomized controlled studies
    • 18
    • PDF
    Reconsidering the Usefulness of Adding Naloxone to Buprenorphine
    • PDF


    Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers.
    • 91
    • PDF
    Self-Administration of Intravenous Buprenorphine and the Buprenorphine/Naloxone Combination by Recently Detoxified Heroin Abusers
    • 91
    • PDF
    The pharmacodynamic and pharmacokinetic profile of intranasal crushed buprenorphine and buprenorphine/naloxone tablets in opioid abusers.
    • 58
    • Highly Influential
    The effects of buprenorphine in buprenorphine-maintained volunteers
    • 51
    • PDF
    Effects of buprenorphine/naloxone in opioid-dependent humans
    • 155
    Comparison of Intravenous Buprenorphine and Methadone Self-Administration by Recently Detoxified Heroin-Dependent Individuals
    • 46
    • PDF
    Effects of buprenorphine and naloxone in morphine-stabilized opioid addicts.
    • 108
    • PDF
    Effects of High-Dose Intravenous Buprenorphine in Experienced Opioid Abusers
    • 38
    Buprenorphine and naloxone interactions in methadone maintenance patients
    • 51