Abuse liability of intravenous buprenorphine vs. buprenorphine/naloxone: Importance of absolute naloxone amount.

@article{Jones2017AbuseLO,
  title={Abuse liability of intravenous buprenorphine vs. buprenorphine/naloxone: Importance of absolute naloxone amount.},
  author={J. Jones and J. Manubay and S. Mogali and Verena E Metz and Gabriela Madera and Suky Martinez and Mudassir Mumtaz and S. Comer},
  journal={Drug and alcohol dependence},
  year={2017},
  volume={179},
  pages={
          362-369
        }
}
  • J. Jones, J. Manubay, +5 authors S. Comer
  • Published 2017
  • Medicine
  • Drug and alcohol dependence
  • BACKGROUND This study sought to determine the relative importance of a range of Bup/Nx doses compared to Bup alone in producing subjective and reinforcing effects. METHODS Heroin-using volunteers (n=13) were transitioned onto daily oral hydromorphone (40mg). Laboratory sessions assessed the reinforcing and subjective effects of intravenous (IV) doses of Bup (1.51, 2.16, 6.15, and 8.64mg) and Bup/Nx (1.51/0.44, 2.16/0.61, 6.15/1.71, and 8.64/2.44mg). Placebo (Pbo), heroin (25mg) and Nx (0.3mg… CONTINUE READING
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