Abuse liability of flupirtine revisited: Implications of spontaneous reports of adverse drug reactions

  title={Abuse liability of flupirtine revisited: Implications of spontaneous reports of adverse drug reactions},
  author={Maximilian Gahr and Roland Wolfgang Freudenmann and Bernhard J. Connemann and Christoph Hiemke and Carlos Sch{\"o}nfeldt-Lecuona},
  journal={The Journal of Clinical Pharmacology},
Early studies suggested that the centrally acting non‐opioid and non‐steroidal analgesic flupirtine (FLP) has no potential for abuse. However, FLP's agonistic effects at the GABAA receptor might prime addictive behaviors, and literature provides some anecdotal reports on FLP abuse/dependence. To shed more light on this topic we acquired and evaluated data obtained from a national German pharmacovigilance database. We analyzed all reports of FLP abuse/dependence that were recorded in the… 
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