Abuse-deterrent opioid formulations: Are they a pipe dream?
@article{Katz2008AbusedeterrentOF, title={Abuse-deterrent opioid formulations: Are they a pipe dream?}, author={Nathaniel Katz}, journal={Current Rheumatology Reports}, year={2008}, volume={10}, pages={11-18} }
The continued need for opioids to treat pain and their unavoidable link to abuse and addiction create a need for risk mitigation approaches that optimize their risk-benefit ratio. Abuse-deterrent formulations (ADFs) have emerged as a means for supporting opioid access while limiting abuse and its consequences. Several different types of ADFs have emerged including physical barriers to tampering, agonist-antagonist formulations, aversion, prodrugs, and alternative methods of administration. Each…
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