Abuse-deterrent opioid formulations: Are they a pipe dream?

@article{Katz2008AbusedeterrentOF,
  title={Abuse-deterrent opioid formulations: Are they a pipe dream?},
  author={Nathaniel Katz},
  journal={Current Rheumatology Reports},
  year={2008},
  volume={10},
  pages={11-18}
}
  • Nathaniel Katz
  • Published 2008
  • Medicine
  • Current Rheumatology Reports
  • The continued need for opioids to treat pain and their unavoidable link to abuse and addiction create a need for risk mitigation approaches that optimize their risk-benefit ratio. Abuse-deterrent formulations (ADFs) have emerged as a means for supporting opioid access while limiting abuse and its consequences. Several different types of ADFs have emerged including physical barriers to tampering, agonist-antagonist formulations, aversion, prodrugs, and alternative methods of administration. Each… CONTINUE READING
    85 Citations

    Tables and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Abuse-Deterrent Opioid Formulations: A Key Ingredient in the Recipe to Prevent Opioid Disasters?
    • 3
    Legal Liability Perspectives on Abuse-Deterrent Opioids in the Treatment of Chronic Pain
    • 15
    Can abuse deterrent formulations make a difference? Expectation and speculation
    • 60
    A practical and ethical solution to the opioid scheduling conundrum
    • 9
    • PDF
    Characterization of Prescription Opioid Abuse in the United States: Focus on Route of Administration
    • 53

    References

    SHOWING 1-10 OF 164 REFERENCES
    Challenges in the Development of Prescription Opioid Abuse-deterrent Formulations
    • 132
    Foundations of Opioid Risk Management
    • 140
    • PDF
    Development of opioid formulations with limited diversion and abuse potential.
    • 55
    Opioid analgesia: perspectives on right use and utility.
    • 155
    Abuse of prescription drugs and the risk of addiction.
    • 431
    Opioids in pain management
    • 371
    Definitions related to the use of opioids for the treatment of pain.
    • Medicine
    • WMJ : official publication of the State Medical Society of Wisconsin
    • 2001
    • 101
    • PDF
    A Profile of OxyContin Addiction
    • L. Hays
    • Medicine
    • Journal of addictive diseases
    • 2004
    • 122