• DOI:10.1038/nature01723
Corpus ID: 4323263

Abundant gene conversion between arms of palindromes in human and ape Y chromosomes

@article{Rozen2003AbundantGC,
  title={Abundant gene conversion between arms of palindromes in human and ape Y chromosomes},
  author={S. Rozen and H. Skaletsky and Janet D. Marszalek and P. Minx and Holland S. Cordum and R. Waterston and R. Wilson and D. Page},
  journal={Nature},
  year={2003},
  volume={423},
  pages={873-876}
}

• S. Rozen, H. Skaletsky, +5 authors D. Page
• Published 2003
• Biology, Medicine
• Nature

Eight palindromes comprise one-quarter of the euchromatic DNA of the male-specific region of the human Y chromosome, the MSY. They contain many testis-specific genes and typically exhibit 99.97% intra-palindromic (arm-to-arm) sequence identity. This high degree of identity could be interpreted as evidence that the palindromes arose through duplication events that occurred about 100,000 years ago. Using comparative sequencing in great apes, we demonstrate here that at least six of these MSY… Expand

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