Abundant gene conversion between arms of palindromes in human and ape Y chromosomes

  title={Abundant gene conversion between arms of palindromes in human and ape Y chromosomes},
  author={S. Rozen and H. Skaletsky and Janet D. Marszalek and P. Minx and Holland S. Cordum and R. Waterston and R. Wilson and D. Page},
  • S. Rozen, H. Skaletsky, +5 authors D. Page
  • Published 2003
  • Biology, Medicine
  • Nature
  • Eight palindromes comprise one-quarter of the euchromatic DNA of the male-specific region of the human Y chromosome, the MSY. They contain many testis-specific genes and typically exhibit 99.97% intra-palindromic (arm-to-arm) sequence identity. This high degree of identity could be interpreted as evidence that the palindromes arose through duplication events that occurred about 100,000 years ago. Using comparative sequencing in great apes, we demonstrate here that at least six of these MSY… CONTINUE READING
    549 Citations

    Paper Mentions

    Large palindromes on the primate X Chromosome are preserved by natural selection
    • PDF
    Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome
    • 2
    Y chromosome palindromes and gene conversion
    • 35
    • Highly Influenced
    Y-Chromosome Structural Diversity in the Bonobo and Chimpanzee Lineages
    • 18
    • PDF
    Extensive gene conversion drives the concerted evolution of paralogous copies of the SRY gene in European rabbits.
    • 25
    • Highly Influenced
    • PDF


    The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
    • 1,856
    • PDF
    Strong male-driven evolution of DNA sequences in humans and apes
    • 243
    • PDF
    Recent Segmental Duplications in the Human Genome
    • 1,279
    Gene conversion and natural selection in the evolution of X-linked color vision genes in higher primates.
    • Y. Zhou, W. Li
    • Biology, Medicine
    • Molecular biology and evolution
    • 1996
    • 43
    • PDF
    Population genetic implications from sequence variation in four Y chromosome genes.
    • P. Shen, F. Wang, +10 authors P. Oefner
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2000
    • 204
    • PDF