Abundant expression of tetraspanin CD9 in activated osteoclasts in ovariectomy-induced osteoporosis and in bone erosions of collagen-induced arthritis

@article{Iwai2007AbundantEO,
  title={Abundant expression of tetraspanin CD9 in activated osteoclasts in ovariectomy-induced osteoporosis and in bone erosions of collagen-induced arthritis},
  author={Kaori Iwai and Masaru Ishii and Shiro Ohshima and Kunio Miyatake and Yukihiko Saeki},
  journal={Rheumatology International},
  year={2007},
  volume={28},
  pages={225-231}
}
Tetraspanin CD9 has been shown to be critically involved in multinucleation and cell fusion during osteoclastogenesis, however, its in vivo pathophysiological role in bone-resorbing disorders such as osteoporosis and rheumatoid arthritis, has not been elucidated. To investigate the involvement of tetraspanin CD9 in bone destruction in such diseases, we… CONTINUE READING