Abundance of the longer A beta 42 in neocortical and cerebrovascular amyloid beta deposits in Swedish familial Alzheimer's disease and Down's syndrome.

@article{Kalaria1996AbundanceOT,
  title={Abundance of the longer A beta 42 in neocortical and cerebrovascular amyloid beta deposits in Swedish familial Alzheimer's disease and Down's syndrome.},
  author={Raj N Kalaria and Debbie L Cohen and Barry D. Greenberg and Mary Josephine Savage and Nenad Bogdanovi{\'c} and Bengt Winblad and Lars Lannfelt and Abdu Adem},
  journal={Neuroreport},
  year={1996},
  volume={7 8},
  pages={1377-81}
}
Recent studies have demonstrated the deposition of amyloid beta (A beta) protein with carboxyl- and aminoterminal heterogeneity in cortical and cerebrovascular deposits of Alzheimer's disease (AD). Using carboxyl end-terminal specific antibodies to A beta peptides, we examined the immunocytochemical distribution of A beta 40 and A beta 42 species in brain tissue from a Swedish subject with familial AD (FAD) bearing the double mutation at codons 670/671 in the amyloid beta precursor protein (A… CONTINUE READING

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