Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function.

@article{Venables1995AbundanceOA,
  title={Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function.},
  author={P. J. W. Venables and Sharon M. Brookes and David J. Griffiths and Robin A Weiss and Mark T. Boyd},
  journal={Virology},
  year={1995},
  volume={211 2},
  pages={589-92}
}
To investigate the hypothesis that the human endogenous sequence ERV-3 has a function, we have cloned and expressed the transmembrane region of its envelope gene and raised specific antibodies to the fusion protein and to a synthetic peptide. These antibodies reacted with a 65-kDa polypeptide which constituted approximately 0.1% of the cellular protein in syncytiotrophoblasts in placenta. The evolutionary conservation and abundant expression of this endogenous retroviral protein in a specific… CONTINUE READING

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