Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity

@article{Ide2010AbundanceOR,
  title={Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity},
  author={Satoru Ide and T. Miyazaki and H. Maki and T. Kobayashi},
  journal={Science},
  year={2010},
  volume={327},
  pages={693 - 696}
}
  • Satoru Ide, T. Miyazaki, +1 author T. Kobayashi
  • Published 2010
  • Biology, Medicine
  • Science
  • Protective Abundance Massively repeated sequences are generally dangerous to genomes because they promote recombination and, potentially, genome instability. Eukaryotic ribosomal RNA genes (rDNA), which are highly transcribed, are organized into large arrays of repeats and have a system that actively maintains these large arrays. In getting to the bottom of this apparent contradiction, Ide et al. (p. 693) found that reducing the number of rDNA repeats in yeast resulted in a marked sensitivity… CONTINUE READING
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