Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity

@article{Ide2010AbundanceOR,
  title={Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity},
  author={Satoru Ide and T. Miyazaki and H. Maki and T. Kobayashi},
  journal={Science},
  year={2010},
  volume={327},
  pages={693 - 696}
}
  • Satoru Ide, T. Miyazaki, +1 author T. Kobayashi
  • Published 2010
  • Biology, Medicine
  • Science
    • Protective Abundance Massively repeated sequences are generally dangerous to genomes because they promote recombination and, potentially, genome instability. Eukaryotic ribosomal RNA genes (rDNA), which are highly transcribed, are organized into large arrays of repeats and have a system that actively maintains these large arrays. In getting to the bottom of this apparent contradiction, Ide et al. (p. 693) found that reducing the number of rDNA repeats in yeast resulted in a marked sensitivity… CONTINUE READING
    View on AAAS
    somosbacteriasyvirus.com
    231 Citations
    Highly Influential Citations
    21
    Background Citations
    109
    Methods Citations
    6
    Results Citations
    3

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

    231 Citations
    Citation Type

    Citation Type

    Ribosomal DNA instability and genome adaptability
    • 18
    • Highly Influenced
    • PDF
    DNA replication stress restricts ribosomal DNA copy number
    • 43
    • PDF
    Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast
    • T. Kobayashi
    • Biology, Medicine
    • Cellular and Molecular Life Sciences
    • 2010
    • 146
    • PDF
    Genome instability: The more, the merrier
    • R. David
    • Biology
    • Nature Reviews Molecular Cell Biology
    • 2010
    RNA Polymerase I Activators Count and Adjust Ribosomal RNA Gene Copy Number.
    • 13
    Rtt109 Prevents Hyper-Amplification of Ribosomal RNA Genes through Histone Modification in Budding Yeast
    • 36
    • PDF
    Genome Instability of Repetitive Sequence: Lesson from the Ribosomal RNA Gene Repeat
    • 4
    Rejuvenation of ribosomal RNA gene repeats at the nuclear pore
    • 1
    Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage
    • 16
    Ribosomal RNA gene repeats, their stability and cellular senescence
    • T. Kobayashi
    • Biology, Medicine
    • Proceedings of the Japan Academy. Series B, Physical and biological sciences
    • 2014
    • 87
    • PDF

    References

    SHOWING 1-10 OF 20 REFERENCES
    Recombination Regulation by Transcription-Induced Cohesin Dissociation in rDNA Repeats
    • 265
    RNA polymerase I transcription obstructs condensin association with 35S rRNA coding regions and can cause contraction of long repeat in Saccharomyces cerevisiae
    • 33
    Abnormality in Initiation Program of DNA Replication Is Monitored by the Highly Repetitive rRNA Gene Array on Chromosome XII in Budding Yeast
    • 32
    • PDF
    Genetics of bacterial ribosomes.
    • 265
    In Exponentially Growing Saccharomyces cerevisiae Cells, rRNA Synthesis Is Determined by the Summed RNA Polymerase I Loading Rate Rather than by the Number of Active Genes
    • 283
    • PDF
    Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae
    • 366
    Identification of cis-acting sites for condensin loading onto budding yeast chromosomes.
    • 294
    • PDF
    A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage
    • 290
    • PDF
    Holliday Junctions Accumulate in Replication Mutants via a RecA Homolog-Independent Mechanism
    • 262
    GFP tagging of budding yeast chromosomes reveals that protein–protein interactions can mediate sister chromatid cohesion
    • 594