Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors.

@article{Woloschak1996AbundanceAS,
  title={Abundance and state of phosphorylation of the retinoblastoma gene product in human pituitary tumors.},
  author={Michael Woloschak and Aiqin Yu and Jiaqi Xiao and Kalmon D. Post},
  journal={International journal of cancer},
  year={1996},
  volume={67 1},
  pages={16-9}
}
Targeted disruptions of the retinoblastoma (Rb) gene result in a high frequency of pituitary tumors in heterozygous mice. While our group and others have reported that loss of heterozygosity (LOH) at the Rb locus in human pituitary tumors is rare, these studies have not excluded small inactivating Rb-gene abnormalities more frequently found in human tumors and undetectable by LOH-PCR assays. As a more sensitive means of detecting evidence of these lesions, we have performed Western-blot… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…