Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants.

@article{Bedaiwy2015AbundanceAL,
  title={Abundance and Localization of Progesterone Receptor Isoforms in Endometrium in Women With and Without Endometriosis and in Peritoneal and Ovarian Endometriotic Implants.},
  author={Mohamed Ali Bedaiwy and Wissam Dahoud and Yelena Skomorovska-Prokvolit and Lijuan Yi and James H. Liu and Tommaso Falcone and William W. Hurd and Sam Mesiano},
  journal={Reproductive sciences},
  year={2015},
  volume={22 9},
  pages={
          1153-61
        }
}
BACKGROUND Several studies suggest that resistance to progesterone may contribute to the pathophysiology of endometriosis. Progesterone mediates its biological activity via the 2 progesterone receptor (PR) isoforms (PR-A and PR-B). Effects of progesterone are determined by the PR-A:PR-B ratio such that a PR-B-dominant state promotes progesterone signaling, whereas a PR-A-dominant state decreases progesterone responsiveness. Our objective was to compare the abundance and cellular localization of… CONTINUE READING
BETA

Similar Papers

Loading similar papers…