Abstracts from the 42nd Kansai Calcium Conference¶April24, 1999 Restaurant Palace Osaka, Osaka, Japan

Abstract

Abstracts from the 42nd Kansai Calcium Conferences from the 42nd Kansai Calcium Conference April 24, 1999 Restaurant Palace Osaka, Osaka, Japan Attempts at objective and quantitative evaluation of bone and joint pain by using skin impedance Takuo Fujita1,2, Yoshio Fujii1, Akimitsu Miyauchi3, and Yasuyuki Takagi3 1 Calcium Research Institute, Kishiwada, Japan 2 Katsuragi Hospital, Osaka, Japan 3 National Sanatorium Hyogo Chuo Hospital, Hyogo, Japan Despite the high frequency and importance of bone and joint pain as manifestations at osteoporosis and degenerative joint disease interfering with the quality of life in advancing age, evaluation of the degree of pain so far has depended entirely on the subjective statement of the test subject utilizing pain scores based on questionnaires. To provide an objective background for the sensation of pain and the biological response of the organism, electrodermal phenomena have been studied. Galvanic skin response was used as an indicator of pain. By using the fall of galvanic skin response, we have successfully differentiated the analgesic effect of chicken calcitonin (avicatonin) from that of a placebo, which was not possible by the pain score method based on questionnaires. Skin impedance, more stable than galvanic resistance, was subsequently measured with reference to bone and joint pain induced by physical stimuli. A skin impedance meter produced by Fukuda Electric conducted Fourier analysis on the voltage pattern induced by a 3-Hz sine wave applied between two electrodes on the palm. Coefficient of variation was 12.4% over a period of 1 month and 2.1% within 5 min of the same day. Skin impedance tended to be higher with advance in age, especially in females. On applying painful stimulus such as knee bending in osteoarthritis of the knee and bending of the back in spondylosis deformans, skin impedance fell instantaneously by 20%–60%, with a highly significant correlation r 5 0.869 (P , 0.001) with pain score based on questioning. With effective analgesic treatment, the fall of impedance diminished. The effect of alendronate on hypercalcemia induced by vitamin D pulse therapy in secondary hyperparathyroidism Yoshiaki Takemoto, Kenji Tsuchida, Yuuko Kakiya, Takahiro Nakamura, and Taketoshi Kishimoto Osaka City University Medical School, Osaka, Japan Secondary hyperparathyroidism is one of the most important complications in the maintenance of hemodialyzed patients. Vitamin D pulse therapy is effective to inhibit the plasma parathyroid hormone level, which indicates the function of parathyroid and plasma ALP levels, reflecting osteoblast activity. The common side effect of this therapy is hypercalcemia. If hypercalcemia can be inhibited, this therapy is more effective for treating secondary hyperparathyroidism. Alendronate is an aminobisphosphonate that acts as a potent inhibitor of osteoclastic bone resorption. This drug inhibited the increase in plasma calcium level induced by malignant tumors. Therefore this study aimed at evaluating the effectiveness of alendronate on inhibition of hypercalcemia induced by Vitamin D pulse therapy. Three patients who received vitamin D pulse therapy participated in this study. All patients received 6 μg or 4μg of calcitorial once or twice a week; 10mg of alendronate was injected two times, once a month. The plasma calcium level was measured before and after injection of alendronate. The changes of plasma calcium level were as follows: before the first injection, 5.33 6 0.23 mEq/l; 1 week after the first injection, 4.97 6 0.45 mEq/l; 2 weeks after the first injection, 4.7 6 0.14 mEq/l; before the second injection, 5.4 6 0.15mEq/ l; 1 week after the second injection, 4.63 6 0.15 mEq/l; 2 weeks after the second injection, 4.97 6 0.15 mEq/l. These results indicated the usefulness of alendronate to inhibit the hypercalcemia induced by vitamin D pulse therapy. The Miyama Cohort Study: Part 1. Distribution of the bone mineral density of the participants in the second cohort M. Takaoka, T. Okawa, C. Mori, A. Kawashima, M. Hayashi, N. Yoshimura, S. Morioka, K. Sakata, and T. Hashimoto The aim of this study was to clarify the distribution of bone mineral density (BMD) of the lumbar spine and proximal femur and lifestyle factors of general inhabitants of the second cohort established in Miyama Village, Wakayama Prefecture, Japan. The BMDs of subjects in the second cohort were also compared with those of participants in the first one. As the second cohort, 50 men and 50 women in each decade of two age strata (40–49 and 50–59 years), totaling 200 inhabitants, were selected randomly. After completion of a interviewer-administered questionnaire, which included lifestyle information such as past history, smoking habits, alcohol consumption, physical activity, sun exposure, tooth loss, and reproductive variables (in women), BMD measurement was performed using the same DXA instrument as for the first cohort. BMD measurements were obtained from 190 participants (90 men and 100 women). In the second cohort, BMDs at the lumbar spine were 1.22g/cm2 for men in their forties and 1.14g/cm2 in their fifties, and those in women were 1.22g/cm2 in their forties and 1.05g/cm2 in their fifties. BMDs at the femoral neck in men were 0.98g/cm2 in their forties and 0.94 g/cm2 in their fifties, and those in women were 0.91g/cm2 in their forties and 0.94g/cm2 in their fifties. There were no significant differences between BMDs at the lumbar spine of the first and second cohort, whereas BMDs at the femoral neck in women in their fifties were significantly higher in the second cohort than in the first cohort (P , 0.05). The Miyama Cohort Study: Part 2. Lifestyle factors and bone mineral density among the participants in the second cohort T. Okawa, M. Takaoka, C. Mori, M. Hayashi, A. Kawashima, N. Yoshimura, S. Morioka, K. Sakata, and T. Hashimoto The aim of this study was to assess lifestyle factors as the risk factors for low bone mineral density (BMD) of general inhabitants of the second cohort established in Miyama Village, Wakayama Prefecture, Japan. The method of sampling for participants and items of the survey have been described in detail in the first lecture. Factors related to BMDs were detected by multiple regression analysis. Lumbar spine BMD was utilized as an objective factor and the following potential risk factors as explanatory variables: alcohol consumption, smoking habit, frequency of milk intake, physical activity, walking time, sun exposure, tooth loss, menstrual status, and estrogen therapy. The analysis was adjusted for age and weight. Partial regression coefficients for lumbar spine BMD were significantly related to alcohol consumption and smoking habit in men, and to tooth loss and time spent walking in women (P , 0.05). Thus, heavy drinking and heavy smoking among men and tooth loss and short walking time (exercise) in daily life among women were related to low bone mass in the second cohort. Serum leptin concentration in relation to bone mineral density and vertebral fracture incidence in postmenopausal women Mika Yamauchi, Toshitugu Sugimoto, Daiki Nakaoka, Michiko Kanzawa, Shozo Yano, Rieko Oozuru, Takeshi Sugishita, and Kazuo Chihara Third Division, Department of Medicine, Kobe Univercity School of Medicine, Kobe, Japan Although fat body mass (FBM) is considered to be one of the determinants of bone mineral density (BMD), its exact mechanism has not been clarified. On the other hand, leptin, the product of the ob gene, is produced in adipocytes, and a close relationship between serum leptin concentration and %fat (FBM divided by total body weight 3100) exists. Recent evidence has made apparent the relation of leptin to osteoblast differenetiation. In this study, we analyzed the relation of leptin to BMD as well as the incidence of vertebral compression fracture when %fat was taken into account. One hundred thirty-nine postmenopausal women (age, 48–78 years; mean, 62.5), who visited our outpatient clinic for osteoporosis examinations, were recruited into this study. Serum leptin concentration was measured by radioimmunoassay. BMD of the lumbar spine (L2–L4), femoral neck, and whole body as well as body composition were measured by DXA, and BMD at the distal one-third of the radius by singleproton absorptiometry (SPA). Leptin and %fat had no correlation with age. Strong positive correlation was found between leptin and %fat (r 5 0.563, P , 0.001). Leptin was positively correlated with BMD at all sites, and multiple regression analysis revealed that leptin was significantly correlated with femoral neck and 46 Abstracts from the 42nd Calcium Conference

DOI: 10.1007/s007740050010

Cite this paper

@article{Fujita2000AbstractsFT, title={Abstracts from the 42nd Kansai Calcium Conference¶April24, 1999 Restaurant Palace Osaka, Osaka, Japan}, author={Takuo Fujita and Yoshio Fujii and Akimitsu Miyauchi and Yasuyuki Takagi and Yoshiaki Takemoto and Kenji Tsuchida and Yuuko Kakiya and Takahiro Nakamura and Taketoshi Kishimoto}, journal={Journal of Bone and Mineral Metabolism}, year={2000}, volume={18}, pages={45-50} }