Abstracting the dynamics of biological pathways using information theory: a case study of apoptosis pathway

@article{Palaniappan2017AbstractingTD,
  title={Abstracting the dynamics of biological pathways using information theory: a case study of apoptosis pathway},
  author={Sucheendra K. Palaniappan and François Bertaux and Matthieu Pichen{\'e} and Eric Fabre and Gr{\'e}gory Batt and Blaise Genest},
  journal={Bioinformatics},
  year={2017},
  volume={33},
  pages={1980–1986}
}
Motivation: Quantitative models are increasingly used in systems biology. Usually, these quantitative models involve many molecular species and their associated reactions. When simulating a tissue with thousands of cells, using these large models becomes computationally and time limiting. Results: In this paper, we propose to construct abstractions using information theory notions. Entropy is used to discretize the state space and mutual information is used to select a subset of all original… CONTINUE READING

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