Abstract LB-302: Whole genome sequencing reveals a significant role of ZNFs-PHLPP2-AKT axis in familial breast cancer of chaoshan area

@article{Fang2019AbstractLW,
  title={Abstract LB-302: Whole genome sequencing reveals a significant role of ZNFs-PHLPP2-AKT axis in familial breast cancer of chaoshan area},
  author={C. Fang and Qian-Qian Ye and Jing Liu and Guojun Zhang},
  journal={Cancer Research},
  year={2019},
  volume={79}
}
Introduction Up to 15% cases of breast cancer are familial. However, the two most prevalent susceptibility genes, BRCA1 and BRCA2, only account for 25% of the familial cases. To this regard, we aimed to identify recurrent variants associated with familial breast cancer in Chaoshan Area of China by whole genome sequencing. Materials & Methods In the present study, Whole Genome Sequencing was performed in 8 familial breast cancer families with 13 familial breast cancer cases and 25 healthy… Expand