Abstract IA09: Inflammation and immunity in pulmonary premalignancy

  title={Abstract IA09: Inflammation and immunity in pulmonary premalignancy},
  author={Kostyantyn Krysan and Linh M. Tran and Brandon Scott Grimes and Steven Dubinett},
Unleashing the immune response against pulmonary premalignancy could transform therapy and outcomes. We are evaluating the mutational landscape of pulmonary premalignancy and the associated premalignant microenvironment by whole-exome DNA sequencing and immunohistochemistry. Remarkably, we find putative neoepitopes and frequent immune-effector cell infiltration as well as evidence of immune suppression in pulmonary premalignancy. These findings suggest that premalignant-associated antigens are… CONTINUE READING

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