Abstract C120: Quantitative analysis of ERK phosphorylation by single cell phospho-specific flow cytometry in colon cancer cells as an input for pharmacokinetic/pharmacodynamic modeling of U0126 concentration.

@inproceedings{Hwang2011AbstractCQ,
  title={Abstract C120: Quantitative analysis of ERK phosphorylation by single cell phospho-specific flow cytometry in colon cancer cells as an input for pharmacokinetic/pharmacodynamic modeling of U0126 concentration.},
  author={Jee Won Hwang and Joong Bae Ahn and Sun Young Rha and Juhye Roh and Hyun Cheol Chung and Soo Hyeon Bae and Sang Joon Shin},
  year={2011}
}
Background: To evaluate intracellular levels of phosphorylated proteins in many signaling pathways, Western blot, immunohistochemical and immufluorescence have been generally used until now. However, to establish pharmacokinetics-pharmacodynamics modeling of various drugs including antitumor agents, precise quantitative measurements of intracellular level of phosphorylated signaling molecules are critically needed. Methods and Materials: In this study, we investigated the ability of single cell… CONTINUE READING

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