Abstract A58: Wnt signaling pathway components are associated with telomerase activity in breast cancer

@inproceedings{Listerman2011AbstractAW,
  title={Abstract A58: Wnt signaling pathway components are associated with telomerase activity in breast cancer},
  author={Imke Listerman and Francesca S Gazzaniga and Laura M. Heiser and Jason Jerome Lukas and Theodore Charles Goldstein and Shaun D. Fouse and Joe W. Gray and Elizabeth H Blackburn},
  year={2011}
}
Telomerase is a ribonucleoprotein complex that adds TTAGGG repeats to telomeres in a highly regulated fashion. Telomerase activity is absent in normal somatic cells, thus limiting their number of cell divisions due to telomere shortening. In contrast, the large majority of tumor cells upregulate telomerase activity, consistent with their ability to maintain stable telomere lengths and to divide indefinitely. Telomerase activity is detectable in over 90% of breast tumors, and it is well… CONTINUE READING