Abstract 4669: Targeting hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells

@article{FaioFlores2016Abstract4T,
  title={Abstract 4669: Targeting hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells},
  author={Fernanda Fai{\~a}o-Flores and D{\'e}bora Kristina Alves-Fernandes and Paula Comune Pennacchi and Silvana Sandri and Anna Luiza Silva Almeida Vicente and Cristovam Scapulatempo-Neto and Vinicius de Lima Vazquez and Rui Manuel Reis and Keiran S. M. Smalley and Silvya Stuchi Maria-Engler},
  journal={Cancer Research},
  year={2016},
  volume={76},
  pages={4669-4669}
}
Melanoma represents the deadliest of all skin cancers being responsible for more than 75% of skin cancer-related deaths. Although the results with BRAF inhibitors have been very promising, practically all of the patients treated thus far have developed resistance to these drugs. The Hedgehog (Hh) signaling pathway has been implicated in a variety of malignancies, including melanoma. However, there are no reports on the activation of this pathway in the setting of vemurafenib-resistance. Herein… 
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TLDR
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