Abstract 4023: Novel role of neurofibromin in transport of RNA granules

@inproceedings{Arun2010Abstract4N,
  title={Abstract 4023: Novel role of neurofibromin in transport of RNA granules},
  author={Vedant Arun and Joseph M. Wiley and Zia Karim and Abhijit Guha},
  year={2010}
}
Neurofibromatosis 1 (NF1) is the most common tumor predisposing syndrome in humans, with an incidence of 1:3500 live births. Neurofibromin, encoded by Nf1, acts as a p21-Ras-GAP to directly interact with and inactivate p21-Ras, through its’ GAP Related Domain (GRD). Evidence suggests that non-Ras-GAP functions mediated through interactions with domains outside of the GRD are of importance. By making a number of NF1-GST domain constructs coupled with differential Mass Spec analysis, we… CONTINUE READING

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