Abstract 3568: Phosphatidylserine targeting antibody enhances antitumor activity of CAR T cells in mouse melanoma

@inproceedings{Schad2018Abstract3P,
  title={Abstract 3568: Phosphatidylserine targeting antibody enhances antitumor activity of CAR T cells in mouse melanoma},
  author={Sara Schad and Daniel Hirschhorn-Cymerman and Sadna Budhu and Hong Zhong and Xia Yang and Joseph S. Shan and Steven King and Taha Merghoub and Jedd D Wolchok},
  year={2018}
}
A viable strategy to treat advanced cancers includes transferring of tumor-specific T cells. T cells that recognize tumor antigens can be expanded and reinvigorated ex-vivo. Furthermore, autologous T cells can be genetically modified to express antitumor T cell receptors or chimeric antigen receptors (CARs). Although the potency and specificity of tumor-specific T cells can be manipulated ex vivo, once reinfused into patients, the T cells are subjected to immunosuppressive mechanisms… CONTINUE READING